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KMID : 1149220090170020187
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Korean Journal of Oriental Medical Prescription
2009 Volume.17 No. 2 p.187 ~ p.194
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Study on Kidney Toxicities of WK-38 for Treatment Vascular Diseases in Rats
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Kim Eun-Ju
Lee An-Sook
Shin Sun-Woo
Kim Sung-Yeon
Chang Bo-Yoon
Lee Ho-Sub
Kang Dae-Gill
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Abstract
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The kidney toxicities of WK-38 used for improvement of the vascular diseases, was examined using male and female Sprague-Dawley rats. The male and female rats were divided into 4 groups for intragastrical treatment with doses of 0, 5, 50, and 500 mg/kg/day for 13 weeks, respectively. In all male and female rats treated with WK-38, no mortality and gross pathological findings were shown for 13 weeks. There was substantially no change in body weight in all rats with treatment of WK-38. Urine osmolality as renal functional parameters were not exchanged in all rats treated with WK-38. The renal functional parameters including electrolytes excretory rate, creatinine clearance, and solute-free water reabsorption were significantly augmented on account of increase in urinary volume in female rats treated with WK-38, but not male. In summary, this study demonstrates that WK-38 exhibits no toxicity on kidney in all male and female rats.
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KEYWORD
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WK-38, Kidney toxicity, In vivo
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